Neurobiological of the autonomic nervous system (ANS)
GENERAL AIMS OF THE COURSE
To improve the understanding of the neurobiology of the AUTONOMIC NERVOUS SYSTEM (ANS) order to enhance the understanding of clinical issues of patients referred to osteopathic or manual medicine.
SPECIFIC AIMS OF THE COURSE
- To review the anatomy and physiology of the peripheral and central ANS
- To expose participants to the current concepts of the neurobiology of the peripheral and central ANS
- To review the mechanisms of regulation of the ANS in health and disease, with reference to current concepts.
Day 1 (20. 6. 2019)
Lecture 1 General neurobiology of the autonomic nervous system: a concept
Lecture 2 Functional anatomy of the peripheral autonomic nervous system
Lecture 3 The final autonomic pathway and its functions
Lecture 4 Transmission of signals in the peripheral ANS: ganglionic and neuroeffector
Day 2 (21. 6. 2019)
Lecture 5 Activity in autonomic neurons in vivo: the result of central integration
Lecture 6 The enteric nervous system
Lecture 7 Spinal autonomic systems: the spinal cord as organ of integration
Lecture 8 Regulation autonomic functions by the lower brain stem: concept and functional
Day 3 (22. 6. 2019)
Lecture 9 Integration of homeostatic regulations and behavior: hypothalamus and telencephalon
Lecture 10 Regulation of the gastrointestinal tract by the brain: vagal and spinal intestino-
intestinal systems and brain
Lecture 11 The vagal afferent system: organ regulation & communication between body domains
Lecture 12 The “whole-body approach ” in osteopathy and modern neurobiology of the regulation
of the body –does this fit together?
The Basic Idea of the Course:
Lectures: In these lectures we will present ideas about the neurobiology (anatomy, physiology, some molecular-biological aspects) of the autonomic nervous system (ANS). We will connect the neurobiology of the ANS with pathophysiological aspects underlying diseases. Lecture 11 concentrates specifically on the functions of vagal afferents in the context of nociception and pain, sickness behavior, inflammatory processes, integration of regulation of the visceral and deep somatic body domains etc. In Lecture 12 we will discuss the idea of “whole body approach” in osteopathy in the light of modern neurobiology of the regulation of body tissues.
The participants are explicitly encouraged to ask questions in case they cannot follow our argumentation and presentation of the data. We would wish that the participants make themselves familiar with articles we have published recently in English textbooks (see below).
Discussion Sessions: Some topics that have been lectured may be extended in the Discussion Sessions on the same day or the next day. Otherwise does the time of the discussion sessions serve as time buffer in case it has already been used by the questions coming from the participants.
Literature: We will supply the participants for their own use with some literature we have published recently for clinicians and basic scientists
Baron, R., Jänig, W. Mechanisms Underlying Complex Regional Pain Syndrome. Role of the Sympathetic Nervous System. In Mathias, C.J., Bannister, R. (eds.) “Autonomic Failure”. Oxford University Press, Oxford, 5. edition, pp. 835-846 (2013)
Jänig, W. Autonomic nervous system and pain. In Basbaum, A.I. Bushnell, M.C. (eds.) Science of Pain. Academic Press, San Diego, pp. 193-225 (2009)
Jänig, W. Functions of the autonomic nervous system: Current concepts. In King, H.H., Jänig, W., Patterson, M.M. (eds.) The Science and Clinical Application of Manual Therapy. Churchill Livingstone Elsevier, Edinburgh, pp. 15-53 (2011)
Jänig W. The autonomic nervous system and pain: neurobiological mechanisms. In Mathias, C.J., Bannister, R. (eds.) Autonomic Failure. Oxford University Press, Oxford, 5. edition, pp. 236-246 (2013)
Jänig, W. The autonomic nervous system. In Galizia, G., Lledo, J.-M. (eds.) Neurosciences – From Molecule to Behavior: A University Textbook. Springer-Verlag, Berlin Heidelberg, pp. 179 – 211 (2013)
Jänig, W. Autonomic nervous system and inflammation: a conceptual view. Autonomic Neuroscience. Basic and Clinical 182, 4-14 (2014)
Jänig, W., Böhni, U., von Heymann, W. Interozeption, Schmerz und vegetatives Nervensystem. In: Böhni, U., Lauper, M., Locher, H. (eds.) Manuellen Medizin I: Fehlfunktion und Schmerz am Bewegungsorgan verstehen und behandeln. Georg Thieme Verlag, Stuttgart New York, pp. 69 –
Jänig, W., Levine, J.D. Autonomic, endocrine, and immune interactions in acute and chronic pain. In McMahon, S.B., Koltzenburg, M., Tracey I, Turk DC (eds.) Wall and Melzack´s Textbook of Pain, 6. edition, Elsevier Churchill Livingstone, Amsterdam Edinburgh, pp. 205-218 (2013)
Jänig, W., McLachlan, E.M. Neurobiology of the autonomic nervous system. In Mathias, C.J., Bannister, R. (eds.) Autonomic Failure. Oxford University Press, Oxford, 5. edition, pp. 22 – 34 (2013)
Kirillova-Woytke, I., Baron, R., Jänig, W. Reflex inhibition of cutaneous and muscle vasoconstrictor neurons during stimulation of cutaneous and muscle nociceptors. J. Neurophysiol. 111, 1833-1845 (2014)
Böhni, U., Lauper, M., Locher, H. (eds.) Manuelle Medizin I: Fehlfunktion und Schmerz am Bewegungsorgan verstehen und behandeln. Georg Thieme Verlag, Stuttgart New York (2015)[will be translated into English]
Craig, A.D. (Bud) How do you feel? An interoceptive moment with your neurobiological self. Princeton University Press. Princeton, Oxford (2015)
Fischer, L., Peuker, E. (eds.) Integrative Schmerztherapie. Carl F. Haug Verlag (MVS Medizinverlage) Stuttgart (2011)
Furness, J.B. The enteric nervous system. Blackwell (2006)
Jänig, W. The Integrative Action of the Autonomic Nervous System. Neurobiology of Homeostasis. Cambridge University Press, Cambridge (2006) [the science of the autonomic nervous system]
Jänig, W., Schaumann, R., Vogt, W. (eds.) CRPS. Complex Regional Pain Syndrome. SUVACARE, Luzern (2013) [this topic is one of my specialities; the version in German, French and soon in Italian can be downloaded under http://www.SUVA.ch/waswo/2771.d]
King, H.H., Jänig, W., Patterson, M.M. (eds.) The Science and Clinical Application of Manual Therapy. Churchill Livingstone Elsevier, Edinburgh (2011) [the only book of this type; I was the driving force behind it; it has been translated into Italian and may be translated into Spanish]
Mathias, C.J., Bannister, R. (eds.) Autonomic Failure. Oxford University Press, Oxford, 5. Auflage, 2013 [at the moment the best and most extensive multi-author textbook on the neurobiology, pathophysiology and clinics of the autonomic nervous system]
Robertson, R., Biaggioni, I., Burnstock, G., Low, P.A., Paton, J.F.R. (Herausgeb.) Primer of the autonomic nervous system. 3rd edition, Elsevier Academic Press, Oxford, (2012) [a book to get a fast orientation]